Pre-Workout 3.0

Pre-Workout 3.0
Pre-Workout 3.0
Pre-Workout 3.0
Pre-Workout 3.0

Pre-Workout 3.0

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The #1 Daily Driver Pre-Workout

Pump + Focus + Energy = Performance

Lack motivation to get to the gym after a long day, or simply looking for an edge in your performance? You came to the right place.

As the science is always changing and new trials are being conducted, we continue research and development to ensure our products abide by what is clinically relevant.

Pre 3.0 was formulated using natural ingredients found to promote an improvement in strength, endurance and cognition.

Based on our knowledge of performance enhancement, we understand that pre-workouts excessively high in caffeine may ‘borrow from tomorrow’ and there are many more vectors to optimize in the field of ergogenic aids other than high doses of caffeine; with Pre 3.0, you are getting much more than just caffeine. 

We abstain from using poorly tolerable ingredients which are deemed unsafe. Instead, we opted to use a variety of unique nutraceuticals and nootropics which synergize together, targeting different metabolic pathways to achieve optimal performance outcomes.

After months of research and development, we present Pre 3.0; replete with the most evidence-based ingredients and informed by rigorous clinical trials in the Journal of the International Society of Sports Nutrition and the clinical expertise of our scientific team.

 

L-Citrulline

L-Citrulline is a precursor to L Arginine and has shown greater clinical efficacy in increasing serum L Arginine levels in comparison to supplementing with pure L Arginine on a gram for gram basis. Increasing L Arginine leads to increased nitric oxide production and thus more vasodilation. In addition to promoting better pumps, L Citrulline is an important rate limiting substrate in the urea cycle, meaning that it contributes to the conversion of ammonia into urea; this is important as hard training increases protein breakdown; thus leading to increased levels of ammonia which is a byproduct that when present in excess can lead to brain fog. L Citrulline may help the body to increase its natural elimination of nitrogenous waste following a workout [20,21].


Beta Alanine

Beta Alanine is an incredibly effective oral agent for the purposes of increasing muscle carnosine levels and work capacity under load; being especially noticeable in high rep ranges and bouts of near-maximal cardio [12,13]. 

There has also been a measurable improvement in cognitive performance in athletes supplementing with Beta Alanine, as it directly activates sensory neurons; causing a temporary itch sensation (paresthesia) which many find to be quite enjoyable / stimulating [12,13].


Betaine Anhydrous

Betaine is a nutrient found in beets that has been shown in recent trials to promote improved training outcomes when taken as a pre workout. It is an osmolyte and may improve hydration status when consumed with sufficient amounts of water. The latest evidence states that 2g of betaine taken pre workout led to improved upper- & lower-body muscle endurance and increased testosterone levels in athletes [16].


Malic Acid

Malic Acid is a Kreb’s cycle intermediate which may increase the availability of energy substrates, being especially useful for generating energy when one is approaching muscular glycogen depletion during a workout.


Taurine

Taurine is a non proteinogenic amino acid which plays a role in regulating fluid balance and neurochemistry. Taurine promotes cell volume homeostasis, helping in situations of dehydration / fluid retention thus positively affecting fluid balance [6,7].

Taurine increases activity of the GABA-A receptor which may explain why it synergizes well with caffeine and other stimulants, by 'taking the edge off' certain stimulants.

Taurine has been shown to improve athletic performance and increase the tolerability of caffeine by ameliorating some of the vasoconstricting properties some may experience with stimulants [6,7].


L-Tyrosine

L-Tyrosine is an amino acid precursor of dopamine, epinephrine and norepinephrine. Several trials support the hypothesis that increasing serum L-Tyrosine levels can improve mental performance especially in states where one might be lacking sufficient sleep or is subject to environmental stressors [1]. 

Leveraging the effects of dopamine during activities that one might not necessarily enjoy is a powerful tool to find pleasure in certain activities and increase adherence to a workout routine.


Alpha GPC

Alpha GPC is amongst the best sources of choline, increasing acetylcholine levels in the brain and improving power output in athletes. Acetylcholine is necessary in the triggering of synapses, being used in the neuromuscular junction to trigger the firing of motor neurons [5]. 

This may also result in increased muscle fiber recruitment / mind-muscle connection, improved learning abilities and a greater attention span [11].


Caffeine Anhydrous

Caffeine is a central nervous system stimulant found in nature and is also classified as a drug of the methylxanthine class. It promotes wakefulness, enhances physical performance, promotes weight loss and increases feelings of wellbeing if dosed correctly [9].

Individual responses to caffeine may vary significantly amongst individuals as some have greater tolerance or are rapid metabolizers, in which caffeine doesn't affect them as greatly; while some are slow metabolizers or are simply just caffeine naive. It is best to start at one scoop to assess tolerance and not to exceed the maximum 3 scoop serving size.


L-Theanine

L-Theranine is a pro-GABAergic amino acid which has shown synergy with caffeine in promoting increased focus and feelings of perceived well-being. This ingredient is a sound way to improve the experience of caffeine in both caffeine tolerant & caffeine naive users.


Theobromine

Theobromine is a methylxanthine which is structurally similar to caffeine but does not provide the same degree of central nervous system stimulation. Instead, theobromine was used many years ago as a bronchodilator before being succeeded by the later drug, theophylline. Theobromine also has previously been used as a vasodilator, as it has been shown to increase intracellular levels of cAMP (which can promote improved vasodilation) [17].


Huperzine A

Huperzine A is the active component in Huperzia Serrata extract. Huperzine A partially inhibits acetylcholinesterase, the enzyme that breaks down acetylcholine; this inhibition can lead to greater levels of acetylcholine in the synaptic cleft and has translated into improved cognitive performance in several randomized controlled trials [10,22].

Sodium Nitrate

Sodium Nitrate is popular within the cyclist community and has been shown to be a positive ergogenic aid in aerobic and anaerobic exercise in humans. Supplementing with nitrates is an

effective way to increase nitric oxide production which leads to increased blood flow to the working tissues. Increasing tissue perfusion (blood flow) during exercise can help reduce the aerobic cost of exercise to the working muscle (by improving the ventilation: perfusion ratio), thus leading to improved cardiovascular function and better endurance during exercise [14].


NADH

NADH is the reduced form of NAD+, a compound that exists within our body that has been supported in a recent meta analysis to be an excellent supplement for ameliorating fatigue, providing the greatest benefits in those who suffer from chronic fatigue syndrome [3].

NADH is taken up by the mitochondria and is a critical component in generating cellular energy (functioning as an electron transporter in the electron transport chain).

NADH has also been supported to:

  • Increase the production of dopamine   
  • Increase general quality of life
  • Reduce symptoms of anxiety
  • Increase maximum achievable heart rate during exercise secondary to an increase in work capacity

As the body utilizes one molecule of NADH, 3 molecules of ATP and one molecule of NAD+ are produced. This means that you can expect to see an increase in power output and endurance with this cutting edge ingredient.

Rhodiola Rosea Extract

Rhodiola Rosea was amongst the first performance enhancing substances first consumed in eastern Europe as an adaptogen for improving training outcomes in the military. A recent meta analysis [15] stated that Rhodiola Rosea supplementation led to the following:

  • A reduction in pain and muscle damage after exercise training.
  • Decreased skeletal muscle damage; enhanced antioxidant capacity thereby reduced oxidative stress.
  • Reduced RPE scores and improved athletic explosive power.


Saffron Extract

Saffron Extract possesses potent mood boosting properties in the literature. With dozens of RCTs (randomized controlled trials) being conducted on saffron extract on a yearly basis, it is established as a widely safe and effective compound in improving one's mood and cognition [4]. 

Through increasing serotonin levels in the brain, it has shown comparable efficacy to Fluoxetine (SSRI) without the associated anhedonia or weight gain frequently seen with SSRIs, additionally, saffron has robust evidence supporting it as a weight loss agent through suppressing one's appetite and improving glucose tolerance (this effect is more pronounced in those who are overweight and/or obese) [4].


Vitamin C

A powerful antioxidant which was included in this formula for two main reasons: 

1) The best time to consume antioxidants is before a workout, in which it may provide a performance benefit.

2) Vitamin C may contribute to a greater increase in vasodilation by attenuating free radical damage and synergizing with the sodium nitrate in this pre workout; thus attenuating the phenomenon of nitrate resistance and promoting the healthy metabolism of nitrates (inhibiting their conversion into nitrosamines while promoting their conversion into nitric oxide) [18].

Vasodrive-AP

A patented blend of two peptides which are derived from milk protein; a recent meta analysis demonstrates that these peptides can reduce systolic blood pressure by up to 5.6mmHg [19]. This reduction in blood pressure was hypothesized to occur due to an ACE inhibitory effect (which was demonstrated in pre-clinical trials), this mechanism of vasodilation is unique in that it is not mediated by nitric oxide.


  1. O'Brien, C., Mahoney, C., Tharion, W. J., Sils, I. V., & Castellani, J. W. (2007). Dietary tyrosine benefits cognitive and psychomotor performance during body cooling. Physiology & behavior, 90(2-3), 301–307. https://doi.org/10.1016/j.physbeh.2006.09.027
  2. Neri, D. F., Wiegmann, D., Stanny, R. R., Shappell, S. A., McCardie, A., & McKay, D. L. (1995). The effects of tyrosine on cognitive performance during extended wakefulness. Aviation, space, and environmental medicine, 66(4), 313–319.
  3. Gindri, I. M., Ferrari, G., Pinto, L. P. S., Bicca, J., Dos Santos, I. K., Dallacosta, D., & Roesler, C. R. M. (2023). Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review. American journal of physiology. Endocrinology and metabolism, 10.1152/ajpendo.00242.2023. Advance online publication. https://doi.org/10.1152/ajpendo.00242.2023
  4. Lu, C., Ke, L., Li, J., Zhao, H., Lu, T., Mentis, A. F. A., Wang, Y., Wang, Z., Polissiou, M. G., Tang, L., Tang, H., & Yang, K. (2021). Saffron (Crocus sativus L.) and health outcomes: a meta-research review of meta-analyses and an evidence mapping study. Phytomedicine : international journal of phytotherapy and phytopharmacology, 91, 153699. https://doi.org/10.1016/j.phymed.2021.153699
  5. Bellar, D., LeBlanc, N. R., & Campbell, B. (2015). The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength. Journal of the International Society of Sports Nutrition, 12, 42. https://doi.org/10.1186/s12970-015-0103-x
  6. Buzdağlı, Y., Eyipınar, C. D., Öget, F., Şıktar, E., Forbes, S. C., & Tekin, A. (2023). Taurine supplementation enhances anaerobic power in elite speed skaters: A double-blind, randomized, placebo-controlled, crossover study. Biology of sport, 40(3), 741–751. https://doi.org/10.5114/biolsport.2023.119990
  7. Schaffer, S., & Kim, H. W. (2018). Effects and Mechanisms of Taurine as a Therapeutic Agent. Biomolecules & therapeutics, 26(3), 225–241. https://doi.org/10.4062/biomolther.2017.251
  8. Sun, Q., Wang, B., Li, Y., Sun, F., Li, P., Xia, W., Zhou, X., Li, Q., Wang, X., Chen, J., Zeng, X., Zhao, Z., He, H., Liu, D., & Zhu, Z. (2016). Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study. Hypertension (Dallas, Tex. : 1979), 67(3), 541–549. https://doi.org/10.1161/HYPERTENSIONAHA.115.06624
  9. Grgic, J., Trexler, E. T., Lazinica, B., & Pedisic, Z. (2018). Effects of caffeine intake on muscle strength and power: a systematic review and meta-analysis. Journal of the International Society of Sports Nutrition, 15, 11. https://doi.org/10.1186/s12970-018-0216-0
  10. Sun, Q. Q., Xu, S. S., Pan, J. L., Guo, H. M., & Cao, W. Q. (1999). Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 20(7), 601–603.
  11. Tun, M. K., & Herzon, S. B. (2012). The pharmacology and therapeutic potential of (-)-huperzine A. Journal of experimental pharmacology, 4, 113–123. https://doi.org/10.2147/JEP.S27084
  12. Hoffman, J. R., Landau, G., Stout, J. R., Hoffman, M. W., Shavit, N., Rosen, P., Moran, D. S., Fukuda, D. H., Shelef, I., Carmom, E., & Ostfeld, I. (2015). β-Alanine ingestion increases muscle carnosine content and combat specific performance in soldiers. Amino acids, 47(3), 627–636. https://doi.org/10.1007/s00726-014-1896-7
  13. Liu, Q., Sikand, P., Ma, C., Tang, Z., Han, L., Li, Z., Sun, S., LaMotte, R. H., & Dong, X. (2012). Mechanisms of itch evoked by β-alanine. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(42), 14532–14537. https://doi.org/10.1523/JNEUROSCI.3509-12.2012
  14. Gao, C., Gupta, S., Adli, T., Hou, W., Coolsaet, R., Hayes, A., Kim, K., Pandey, A., Gordon, J., Chahil, G., Belley-Cote, E. P., & Whitlock, R. P. (2021). The effects of dietary nitrate supplementation on endurance exercise performance and cardiorespiratory measures in healthy adults: a systematic review and meta-analysis. Journal of the International Society of Sports Nutrition, 18(1), 55. https://doi.org/10.1186/s12970-021-00450-4
  15. Lu, Y., Deng, B., Xu, L., Liu, H., Song, Y., & Lin, F. (2022). Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review. Frontiers in nutrition, 9, 856287. https://doi.org/10.3389/fnut.2022.856287
  16. Arazi, H., Aboutalebi, S., Taati, B., Cholewa, J. M., & Candow, D. G. (2022). Effects of short-term betaine supplementation on muscle endurance and indices of endocrine function following acute high-intensity resistance exercise in young athletes. Journal of the International Society of Sports Nutrition, 19(1), 1–16. https://doi.org/10.1080/15502783.2022.2041988
  17. Theobromine. https://go.drugbank.com/drugs/DB01412. Accessed 4 Mar. 2024.
  18. Lbban, E., Ashor, A., Shannon, O. M., Idris, I., & Siervo, M. (2023). Is vitamin C a booster of the effects of dietary nitrate on endothelial function? Physiologic rationale and implications for research. Nutrition (Burbank, Los Angeles County, Calif.), 109, 111995. https://doi.org/10.1016/j.nut.2023.111995
  19. Chanson-Rolle, A., Aubin, F., Braesco, V., Hamasaki, T., & Kitakaze, M. (2015). Influence of the Lactotripeptides Isoleucine-Proline-Proline and Valine-Proline-Proline on Systolic Blood Pressure in Japanese Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PloS one, 10(11), e0142235. https://doi.org/10.1371/journal.pone.0142235
  20. Barkhidarian, B., Khorshidi, M., Shab-Bidar, S., & Hashemi, B. (2019). Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis. Avicenna journal of phytomedicine, 9(1), 10–20.
  21. Takeda, K., Machida, M., Kohara, A., Omi, N., & Takemasa, T. (2011). Effects of citrulline supplementation on fatigue and exercise performance in mice. Journal of nutritional science and vitaminology, 57(3), 246–250. https://doi.org/10.3177/jnsv.57.246
  22. Tun, M. K., & Herzon, S. B. (2012). The pharmacology and therapeutic potential of (-)-huperzine A. Journal of experimental pharmacology, 4, 113–123. https://doi.org/10.2147/JEP.S27084
*These statements have not been evaluated by the Food and Drug Administration (FDA).  This product is not intended to diagnose, treat, cure, or prevent any disease.

Customer Reviews

Based on 12 reviews
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G
Gonzalo vidales
Does the job

The flavor is fine. Not as good as there old peach mango that was a 10/10 but definitely does what it needs to do. No crash at the gym. Ill buy it again for sure. I 100% prefer this over any other pre workout ive tried.

J
Jeffrey Theisen
Great!

I've used a lot of pre-workouts and I feel I always get the best workout with HTLT

A
Alexander Bondar
Great taste and powerful

This is the best flavor of them all from the brand. The formulation is great and you can feel the effect within a few mins. after taking it. I only take one scoop and is enough.

E
Eric Mathews
The best and only preworkout I buy anymore

Not only do I not feel sick when taking this, it gives me the energy I need every time, and the flavors are better than any other I've seen!

T
Trevor
Pink candy 3.0

At first I thought this was going ri be a super sweet tasting pre workout. Which personally I am not a fan of. Upon trying this I found this to be actually pleasant! Highly recommend to anyone. Gives you just enough pump to carry you and push you! Will be buying again! Any other flavor recommendations?

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