Signature Series Pre-Workout
Signature Series Pre-Workout
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- Description
- Supplement Facts
- Ingredients
- References:
Lack motivation to get to the gym after a long day, or simply looking for an edge in your performance? You came to the right place.
As the science is always changing and new trials are being conducted, we continue research and development to ensure our products abide by what is clinically relevant.
Our signature series pre workout was formulated using natural ingredients found to promote an improvement in strength, endurance and cognition.
Based on our knowledge of performance enhancement, we understand that pre-workouts excessively high in caffeine may ‘borrow from tomorrow’ and there are many more vectors to optimize in the field of ergogenic aids other than high doses of caffeine; with this product, you are getting much more than just caffeine.
We abstain from using poorly tolerable ingredients which are deemed unsafe. Instead, we opted to use a variety of unique nutraceuticals and nootropics which synergize together to achieve optimal performance outcomes.
After months of research and development, we present our signature series pre workout; replete with the most evidence-based ingredients and informed by rigorous clinical trials in the Journal of the International Society of Sports Nutrition and the clinical expertise of our scientific team.
L-Citrulline and L-Arginine are precursors to nitric oxide, when supplemented in combination they have shown greater clinical efficacy in increasing nitric oxide levels in comparison to supplementing with pure L Arginine or L Citrulline on their own [23]. This may increase the perceived ‘pump’ phenomenon noted by athletes, but more importantly, the outcomes of supplementing with these two amino acids have shown a statistically significant improvement in athletic performance [23].
In addition to promoting better pumps, L Citrulline is an important rate limiting substrate in the urea cycle, meaning that it contributes to the conversion of ammonia into urea; this is important as hard training increases protein breakdown; thus leading to increased levels of ammonia which is a byproduct that when present in excess may worsen mental fatigue. L Citrulline may help the body increase its natural elimination of nitrogenous waste following a workout [20,21].
Beta Alanine is an incredibly effective oral agent for the purposes of increasing muscle carnosine levels, leading to increased work capacity in prolonged periods of muscular load; being especially noticeable in high rep ranges and bouts of near-maximal cardio [12,13].
There has also been a measurable improvement in cognitive performance in athletes supplementing with Beta Alanine, as it directly activates sensory neurons; causing a temporary itch sensation (paresthesia) which many find to be quite enjoyable / stimulating [12,13].
Malic Acid is a Kreb’s cycle intermediate which may increase the availability of energy substrates, being especially useful for generating energy when one is approaching muscular glycogen depletion during a workout.
Caffeine Anhydrous is a central nervous system stimulant found in nature and is also classified as a drug of the methylxanthine class. It promotes wakefulness, enhances physical performance, promotes weight loss and increases feelings of wellbeing if dosed correctly [9].
Individual responses to caffeine may vary significantly amongst individuals as some have greater tolerance or are rapid metabolizers, in which caffeine doesn't affect them as greatly; while some are slow metabolizers or are simply just caffeine naive. It is best to start at one scoop to assess tolerance and not to exceed the maximum 3 scoop serving size.
L-Theanine is a pro-GABAergic amino acid which has shown synergy with caffeine in promoting increased focus and feelings of perceived well-being. This ingredient is a sound way to improve the experience of caffeine in both caffeine tolerant & caffeine naive users.
Huperzine A is the active component in Huperzia Serrata extract. Huperzine A partially inhibits acetylcholinesterase, the enzyme that breaks down acetylcholine; this inhibition can lead to greater levels of acetylcholine in the synaptic cleft and has translated into improved cognitive performance in several randomized controlled trials [10,22].
Sodium Nitrate is popular amongst endurance athletes as it has been shown to be a positive ergogenic aid in aerobic and anaerobic exercise. Supplementing with nitrates is an effective way to increase nitric oxide production which leads to increased blood flow to the working tissues. Nitrate consumption may reduce the aerobic cost of exercise to the working muscle (by improving mitochondrial efficiency), thus leading to improved cardiovascular function and improved endurance outcomes during exercise [14].
Salidroside is one of the primary bioactives of the Rhodiola genus, when isolated on its own, it has shown promise in prolonging tine-to-exhaustion in endurance exercise in addition to improving oxygen uptake (VO2 max) compared to placebo [24].
Saffron Extract possesses potent mood boosting properties in the literature. With dozens of RCTs (randomized controlled trials) being conducted on saffron extract on a yearly basis, it is established as a widely safe and effective compound in improving one's mood and cognition [4].
There is also robust evidence supporting Saffron extract as a weight loss agent, primarily through suppressing one's appetite and improving glucose tolerance (this effect is more pronounced in those who are overweight and/or obese) [4].
Vitamin C is a powerful antioxidant which was included in this formula for two primary indications:
1) Consuming vitamin C prior to a workout may improve performance by reducing exercise induced oxidative stress.
2) Vitamin C may contribute to a greater increase in vasodilation by attenuating free radical damage and synergizing with the sodium nitrate in this pre workout; thus attenuating the phenomenon of nitrate resistance and promoting the healthy metabolism of nitrates (inhibiting their conversion into nitrosamines while promoting their conversion into nitric oxide) [18].
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Neri, D. F., Wiegmann, D., Stanny, R. R., Shappell, S. A., McCardie, A., & McKay, D. L. (1995). The effects of tyrosine on cognitive performance during extended wakefulness. Aviation, space, and environmental medicine, 66(4), 313–319.
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Gindri, I. M., Ferrari, G., Pinto, L. P. S., Bicca, J., Dos Santos, I. K., Dallacosta, D., & Roesler, C. R. M. (2023). Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review. American journal of physiology. Endocrinology and metabolism, 10.1152/ajpendo.00242.2023. Advance online publication. https://doi.org/10.1152/ajpendo.00242.2023
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Lu, C., Ke, L., Li, J., Zhao, H., Lu, T., Mentis, A. F. A., Wang, Y., Wang, Z., Polissiou, M. G., Tang, L., Tang, H., & Yang, K. (2021). Saffron (Crocus sativus L.) and health outcomes: a meta-research review of meta-analyses and an evidence mapping study. Phytomedicine : international journal of phytotherapy and phytopharmacology, 91, 153699. https://doi.org/10.1016/j.phymed.2021.153699
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Bellar, D., LeBlanc, N. R., & Campbell, B. (2015). The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength. Journal of the International Society of Sports Nutrition, 12, 42. https://doi.org/10.1186/s12970-015-0103-x
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Buzdağlı, Y., Eyipınar, C. D., Öget, F., Şıktar, E., Forbes, S. C., & Tekin, A. (2023). Taurine supplementation enhances anaerobic power in elite speed skaters: A double-blind, randomized, placebo-controlled, crossover study. Biology of sport, 40(3), 741–751. https://doi.org/10.5114/biolsport.2023.119990
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Schaffer, S., & Kim, H. W. (2018). Effects and Mechanisms of Taurine as a Therapeutic Agent. Biomolecules & therapeutics, 26(3), 225–241. https://doi.org/10.4062/biomolther.2017.251
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Sun, Q., Wang, B., Li, Y., Sun, F., Li, P., Xia, W., Zhou, X., Li, Q., Wang, X., Chen, J., Zeng, X., Zhao, Z., He, H., Liu, D., & Zhu, Z. (2016). Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study. Hypertension (Dallas, Tex. : 1979), 67(3), 541–549. https://doi.org/10.1161/HYPERTENSIONAHA.115.06624
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Grgic, J., Trexler, E. T., Lazinica, B., & Pedisic, Z. (2018). Effects of caffeine intake on muscle strength and power: a systematic review and meta-analysis. Journal of the International Society of Sports Nutrition, 15, 11. https://doi.org/10.1186/s12970-018-0216-0
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Sun, Q. Q., Xu, S. S., Pan, J. L., Guo, H. M., & Cao, W. Q. (1999). Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 20(7), 601–603.
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Tun, M. K., & Herzon, S. B. (2012). The pharmacology and therapeutic potential of (-)-huperzine A. Journal of experimental pharmacology, 4, 113–123. https://doi.org/10.2147/JEP.S27084
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Hoffman, J. R., Landau, G., Stout, J. R., Hoffman, M. W., Shavit, N., Rosen, P., Moran, D. S., Fukuda, D. H., Shelef, I., Carmom, E., & Ostfeld, I. (2015). β-Alanine ingestion increases muscle carnosine content and combat specific performance in soldiers. Amino acids, 47(3), 627–636. https://doi.org/10.1007/s00726-014-1896-7
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Liu, Q., Sikand, P., Ma, C., Tang, Z., Han, L., Li, Z., Sun, S., LaMotte, R. H., & Dong, X. (2012). Mechanisms of itch evoked by β-alanine. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(42), 14532–14537. https://doi.org/10.1523/JNEUROSCI.3509-12.2012
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Gao, C., Gupta, S., Adli, T., Hou, W., Coolsaet, R., Hayes, A., Kim, K., Pandey, A., Gordon, J., Chahil, G., Belley-Cote, E. P., & Whitlock, R. P. (2021). The effects of dietary nitrate supplementation on endurance exercise performance and cardiorespiratory measures in healthy adults: a systematic review and meta-analysis. Journal of the International Society of Sports Nutrition, 18(1), 55. https://doi.org/10.1186/s12970-021-00450-4
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Lu, Y., Deng, B., Xu, L., Liu, H., Song, Y., & Lin, F. (2022). Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review. Frontiers in nutrition, 9, 856287. https://doi.org/10.3389/fnut.2022.856287
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Arazi, H., Aboutalebi, S., Taati, B., Cholewa, J. M., & Candow, D. G. (2022). Effects of short-term betaine supplementation on muscle endurance and indices of endocrine function following acute high-intensity resistance exercise in young athletes. Journal of the International Society of Sports Nutrition, 19(1), 1–16. https://doi.org/10.1080/15502783.2022.2041988
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Theobromine. https://go.drugbank.com/drugs/DB01412. Accessed 4 Mar. 2024.
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Lbban, E., Ashor, A., Shannon, O. M., Idris, I., & Siervo, M. (2023). Is vitamin C a booster of the effects of dietary nitrate on endothelial function? Physiologic rationale and implications for research. Nutrition (Burbank, Los Angeles County, Calif.), 109, 111995. https://doi.org/10.1016/j.nut.2023.111995
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Chanson-Rolle, A., Aubin, F., Braesco, V., Hamasaki, T., & Kitakaze, M. (2015). Influence of the Lactotripeptides Isoleucine-Proline-Proline and Valine-Proline-Proline on Systolic Blood Pressure in Japanese Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PloS one, 10(11), e0142235. https://doi.org/10.1371/journal.pone.0142235
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Barkhidarian, B., Khorshidi, M., Shab-Bidar, S., & Hashemi, B. (2019). Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis. Avicenna journal of phytomedicine, 9(1), 10–20.
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Takeda, K., Machida, M., Kohara, A., Omi, N., & Takemasa, T. (2011). Effects of citrulline supplementation on fatigue and exercise performance in mice. Journal of nutritional science and vitaminology, 57(3), 246–250. https://doi.org/10.3177/jnsv.57.246
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Tun, M. K., & Herzon, S. B. (2012). The pharmacology and therapeutic potential of (-)-huperzine A. Journal of experimental pharmacology, 4, 113–123. https://doi.org/10.2147/JEP.S27084
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Park, H. Y., Kim, S. W., Seo, J., Jung, Y. P., Kim, H., Kim, A. J., Kim, S., & Lim, K. (2023). Dietary Arginine and Citrulline Supplements for Cardiovascular Health and Athletic Performance: A Narrative Review. Nutrients, 15(5), 1268. https://doi.org/10.3390/nu15051268
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Schwarz, N. A., Stratton, M. T., Colquhoun, R. J., Manganti, A. M., Sherbourne, M., Mourey, F., White, C. C., Day, H., Dusseault, M. C., Hudson, G. M., Vickery, C. R., Schachner, H. C., Kasprzyk, P. G., & Weng, J. K. (2024). Salidroside and exercise performance in healthy active young adults - an exploratory, randomized, double-blind, placebo-controlled study. Journal of the International Society of Sports Nutrition, 21(1), 2433744. https://doi.org/10.1080/15502783.2024.2433744
*These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease. |